![]() This model applies the ARDSNet ‘female’ formula to both adult sexes, while providing a tight fit to median body weight at smaller statures down to pre-term. The ‘PBWuf + MBW’ model is proposed as an appropriate compromise between prevailing practice and simplification, while also better representing lean adult body-weight. Four alternate piecewise-linear lean body-weight predictive formulae were presented for consideration, each with different balance between the objectives. The ARDSNet PBW formulae typically predict weights heavier than the population median, therefore no single relationship could satisfy both references. Error limits for derived PBW models were relative to these references. The traditional ARDSNet PBW formulae acted as the reference for prevailing protective ventilation practice. ![]() Historic population-based growth charts were adopted as a reference for lean body weight, from pre-term infant through to adult median weight. This analysis investigated whether it might be practical to derive a unisex PBW formula spanning all body sizes, while retaining relevance to established adult protective ventilation practice. No agreed PBW formula applies to smaller body sizes. ![]() The predicted body weight (PBW) relationship employed in the ARDS Network trial is considered valid only for adults, with a dedicated formula required for each sex. A component of lung-protective ventilation relies on a prediction of lean body weight from height. This concept has expanded to other areas of acute adult ventilation and is recommended for pediatric ventilation. The lung-protective ventilation bundle has been shown to reduce mortality in adult acute respiratory distress syndrome (ARDS).
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